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Canthaxanthin1
IUPAC name 2,4,4-Trimethyl- 3-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)- 3,7,12,16-tetramethyl-18-(2,6,6-trimethyl-3-oxo- 1-cyclohexenyl)octadeca-1,3,5,7,9,11,13,15,17- nonaenyl]-1-cyclohex-2-enone
Other names Cantaxanthin, Cantaxanthine, Canthaxanthine, Orobronze, Carophyll Red, Roxanthin Red 10, L-Orange 7, C.I. Food Orange 8, β,β-Carotene-4,4'-dione, E161g
Identifiers
CAS number 514-78-3
PubChem 5281227
SMILES
Properties
Molecular formula C40H52O2
Molar mass 564.82 g/mol
Appearance Violet crystals
Melting point

217 °C (decomposition)

Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox references

Canthaxanthin (pronounced /ˌcæn θə ˈzæn ˌθɪn/ canthaxanthin ) is a carotenoid pigment widely distributed in nature. Carotenoids belong to a larger class of phytochemicals known as terpenoids. The chemical formula of canthaxanthin is C40H52O2.2 It has E number E161g.

It was first isolated in edible mushrooms. It has also been found in green algae, bacteria, crustaceans, and fish such as carp, golden mullet, seabream and trush wrasse2.

In the United Kingdom, canthaxanthin is allowed by law to be added to poultry feed, some sausages mainly exported to France, and trout and salmon feed.3 In addition, the European Union has set the limit at 80 mg/kg of foodstuffing.2

Presence in fish

Canthaxanthin is not found in wild Atlantic Salmon, but is a minor carotenoid in Pacific Salmon.2 Canthaxanthin is used in farm-raised trout.2 Canthaxanthin is used in combination with astaxanthin for some salmon feeds.2

Use in tanning pills

FDA has no "tanning pills" approved for sale in the United States. In spite of this, there are companies that continue to market such products, some of which contain canthaxanthin. The FDA considers such items "adulterated cosmetics" and as a result sent "Warning Letters" to the firms citing such products as containing "a color additive that is unsafe within the meaning of section 721(a) of the FD&C Act (FD&C Act, sec. 601(e))."4

According to the FDA:

Tanning pills have been associated with health problems, including an eye disorder called canthaxanthin retinopathy, which is the formation of yellow deposits on the eye's retina. Canthaxanthin has also been reported to cause liver injury and a severe itching condition called urticaria, according to the AAD.5

References

  1. ^ Merck Index, 11th Edition, 1756.
  2. ^ Canthaxanthin - your questions answered - June 13, 2002
  3. ^ Warning Letters Cite Cosmetics as Adulterated Due to Violative Use of the Color Additive Canthaxanthin
  4. ^ From FDA & You Issue #3 - Spring/Summer 2003 - Sun Safety: Protect the Skin You’re In!
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